Medical Pharmacology and Therapeutics by Waller Derek G. & Sampson Tony
Author:Waller, Derek G. & Sampson, Tony [Waller, Derek G.]
Language: eng
Format: epub
ISBN: 9780702055034
Publisher: Elsevier Health Sciences UK
Published: 2013-08-07T00:00:00+00:00
Anti-inflammatory effect
Inhibition of vasodilation and oedema is partly related to a reduction in peripheral COX-2-generated prostaglandin synthesis. However, NSAIDs also affect several other inflammatory processes unrelated to their effects on prostaglandins. For example, they probably reduce harmful superoxide free radical generation by neutrophils. They may also uncouple G-protein-regulated processes in the cell membrane of inflammatory cells, which reduces their responsiveness to a variety of agonists released by damaged tissues. The anti-inflammatory effects of NSAIDs develop gradually over about 3 weeks.
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